Table I.
Correlation of insulin-like growth factor 1 receptor (IGF-1R) expression and mammographic breast density with clinicopathological variables in primary breast cancer.
| IGF-1R expression | Dense breast tissue | ||||||
|---|---|---|---|---|---|---|---|
| Low | High | Negative | Positive | ||||
| Variables | Total (%) | No. (%) | No. (%) | P-value | No. (%) | No. (%) | P-value |
| Age, years | |||||||
| Median, 47 (range, 20–81) | 167 | 104 (62.3) | 63 (37.7) | 0.207 | 97 (58.1) | 70 (41.9) | 0.001 |
| Menopausal status | |||||||
| Premenopausal | 98 (58.7) | 59 (56.7) | 39 (61.9) | 0.338 | 50 (51.5) | 48 (68.6) | 0.889 |
| Postmenopausal | 69 (41.3) | 45 (43.3) | 24 (38.1) | 47 (48.5) | 22 (31.4) | ||
| BMI | |||||||
| <23 | 70 (41.9) | 44 (42.3) | 26 (41.3) | 0.312 | 33 (34.0) | 37 (52.9) | 0.093 |
| ≥23 | 97 (58.1) | 60 (57.7) | 37 (58.7) | 64 (66.0) | 33 (47.1) | ||
| Nuclear grade | |||||||
| 1 | 10 (6.0) | 6 (5.8) | 4 (6.3) | 0.147 | 6 (6.2) | 4 (5.7) | 0.218 |
| 2 | 99 (59.3) | 65 (62.5) | 34 (54.0) | 63 (64.9) | 36 (51.4) | ||
| 3 | 58 (34.7) | 33 (31.7) | 25 (39.7) | 28 (28.9) | 30 (42.9) | ||
| Histological grade | |||||||
| 1 | 28 (16.8) | 18 (17.3) | 10 (15.9) | 0.357 | 23 (23.8) | 5 (7.1) | 0.045 |
| 2 | 88 (52.7) | 53 (51.0) | 35 (55.5) | 50 (51.5) | 38 (54.3) | ||
| 3 | 51 (30.5) | 33 (31.7) | 18 (28.6) | 24 (24.7) | 27 (38.6) | ||
| Tumor size | |||||||
| T1 | 66 (39.5) | 37 (35.6) | 29 (46.0) | 0.145 | 43 (44.3) | 23 (32.8) | 0.828 |
| T2 | 97 (58.1) | 65 (62.5) | 32 (50.8) | 52 (53.6) | 45 (64.3) | ||
| T3 | 4 (2.4) | 2 (1.9) | 2 (3.2) | 2 (2.1) | 2 (2.9) | ||
| Lymph node metastasis | |||||||
| N0 | 92 (55.1) | 58 (55.7) | 34 (54.0) | 0.782 | 60 (61.9) | 32 (45.7) | 0.193 |
| N1 | 44 (26.3) | 29 (27.9) | 15 (23.8) | 23 (23.7) | 21 (30.0) | ||
| N2 | 20 (12.0) | 11 (10.6) | 9 (14.3) | 10 (10.3) | 10 (14.3) | ||
| N3 | 11 (6.6) | 6 (5.8) | 5 (7.9) | 4 (4.1) | 7 (10.0) | ||
| Subtype | |||||||
| Luminal A | 86 (51.5) | 50 (48.1) | 36 (57.1) | 0.670 | 51 (52.6) | 35 (50.0) | 0.842 |
| Luminal B | 21 (12.6) | 12 (11.5) | 9 (14.3) | 14 (14.4) | 7 (10.0) | ||
| HER-2 | 24 (14.4) | 19 (18.3) | 5 (7.9 | 11 (11.3) | 13 (18.6) | ||
| TNBC | 36 (21.5) | 23 (22.1) | 13 (20.7 | 21 (21.7) | 15 (21.4) | ||
| IGF-1R expression | |||||||
| Low (0,1) | 104 (62.3) | 104 (100.0) | 0 (0.0) | 68 (70.1) | 36 (51.4) | 0.021 | |
| High (2,3) | 63 (37.7) | 0 (0.0) | 63 (100.0) | 29 (29.9) | 34 (48.6) | ||
| Dense breast tissue | |||||||
| Negative | 97 (58.1) | 68 (65.4) | 29 (46.0) | 0.021 | 97 (100.0) | 0 (0.0) | |
| Positive | 70 (41.9) | 36 (34.6) | 34 (54.0) | 0 (0.0) | 70 (100.0) | ||
BMI, body mass index; HER-2, human epidermal growth factor receptor 2; TNBC, triple-negative breast cancer.