Table V.

Analysis of factors related to overall survival after operation.

Factors	Patient no.	5-year overall survival (%)	Univariate analysis, P-value	Multivariate analysis, relative risk (CI)
Age (years)			0.28
≥70	20	10.5
≤69	16	46.9
Gender			0.71
Male	21	22.2
Female	15	35.0
pT stage			0.02
pT3	28	16.8		1.66
pT1 and T2	8	62.5		(0.48–6.14)
Tumor size (mm)			0.74
≥25	18	25.4
<25	18	30.4
Nodal metastasis			0.003
Yes	16	15.6		2.76
No	20	39.3		(1.08–7.73)
Lymphatic invasion			0.22
Yes	26	18.8
No	10	30.6
Venous invasion			0.19
Yes	15	17.8
No	21	34.1
Perineural invasion			0.11
Yes	28	24
No	7	37.5
PV invasion			0.39
Yes	11	35.4
No	25	24.8
Arterial invasion			0.74
Yes	3	0.0
No	33	30.5
HK2 staining			0.003
Yes	21	0.0		2.57
No	15	55.7		(0.89–8.39)
PKM2 staining			0.004
Yes	16	0.0		2.16
No	20	47.1		(0.82–6.1)

CI, confidence interval; PV, portal vein; HK2, hexokinase 2; PKM2, pyruvate kinase isoenzyme type M2.