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. 2015 Mar 6;54(17):5232–5235. doi: 10.1002/anie.201500401

Scheme 2.

Scheme 2

Alternative mechanisms for the formation of symmetrical diolide 1 b. Route 1): initial nucleophilic attack by the distal hydroxyl group of the TE-bound monomer on the ACP-bound thioester. Route 2): the TE-bound monomer is attacked by the distal hydroxy group of a second monomer tethered to the adjacent ACP domain.