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Catechol bisphosphate (1) is a selective inhibitor of the STAT5b SH2 domain. a) Structures of Fosfosal[9] and 1. b) Activities of 1 against the SH2 domains of STAT family members and the tyrosine kinase Lck analyzed in binding assays based on fluorescence polarization. c) Binding of 1 to the STAT5b SH2 domain as predicted by docking with AutoDock Vina.
