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Design, synthesis, and biochemical activity of compound 13. a) Docking of 12 into the STAT5b SH2 domain with AutoDock Vina. b) Binding mode of 13 as suggested by docking. c) Synthesis of 13. d) Activities of 13 against the SH2 domains of STAT family members and the tyrosine kinase Lck. e) Comparison of the activities of 13 and the natural peptide ligand QDTpYLVLDKWL (16) against STAT5a and STAT5b.
