Table 1.
Mole fraction partition coefficients in NaC 50 mm, NaDC 25 mm, and NaTC 50 mm.
| Azithromycinaglycone | Decladinosyl-azithromycin | Erythromycin | Azahomoerythromycin | Azithromycin | Clarithromycin | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NaC | 0.29 | +/− | 0.09 | 1.47 | +/− | 0.24 | 2.73 | +/− | 0.63 | 3.03 | +/− | 0.78 | –[*] | –[*] | ||||
| NaDC | 0.50 | +/− | 0.14 | 1.55 | +/− | 0.13 | 1.10 | +/− | 0.05 | 2.64 | +/− | 0.53 | 5.94 | +/− | 0.91 | 3.55 | +/− | 0.53 |
| NaTC | 0.42 | +/− | 0.07 | 1.46 | +/− | 0.12 | 2.73 | +/− | 0.30 | 2.51 | +/− | 0.81 | 11.1 | +/− | 3.0 | 11.5 | +/− | 3.1 |
[*]
Kp values above approximately 15 are unreliable due to huge standard deviations.