Table VI.
Adjusted odds ratios for polymorphisms in folate-related genes and colorectal cancer, stratified by hypertension and diabetes mellitus statusa.
| Hypertension | Diabetes mellitus | |||
|---|---|---|---|---|
| Genotypes | No | Yes | No | Yes |
| N | 455 | 536 | 751 | 240 |
| Total | 1.00 (reference) | 1.72 (1.31–2.26) | 1.00 (reference) | 2.73 (2.00–3.73) |
| MTHFR 677C>T | ||||
| CC+CT | 1.00 (reference) | 1.59 (1.19–2.14) | 1.00 (reference) | 2.73 (1.94–3.83) |
| TT | 1.00 (reference) | 2.74 (1.30–5.79) | 1.00 (reference) | 3.16 (1.41–7.12) |
| MTHFR 1298A>C | ||||
| AA | 1.00 (reference) | 1.52 (1.10–2.09) | 1.00 (reference) | 2.77 (1.91–4.04) |
| AC+CC | 1.00 (reference) | 2.52 (1.49–4.26) | 1.00 (reference) | 2.67 (1.51–4.73) |
| TSER 2R/3R | ||||
| 3R3R | 1.00 (reference) | 1.90 (1.36–2.65) | 1.00 (reference) | 3.07 (2.07–4.56) |
| 2R3R+2R2R | 1.00 (reference) | 1.41 (0.88–2.27) | 1.00 (reference) | 2.26 (1.35–3.80) |
| TS 1494 0bp/6bp | ||||
| 0bp0bp | 1.00 (reference) | 2.08 (1.41–3.06) | 1.00 (reference) | 2.50 (1.62–3.87) |
| 0bp6bp+6bp6bp | 1.00 (reference) | 1.41 (0.96–2.08) | 1.00 (reference) | 3.10 (1.97–4.88) |
| MTHFR 677/1298 | ||||
| CC+CT/AA | 1.00 (reference) | 1.30 (0.90–1.86) | 1.00 (reference) | 2.80 (1.82–4.30) |
| CC+CT/AC+CC | 1.00 (reference) | 2.52 (1.49–4.26) | 1.00 (reference) | 2.67 (1.51–4.73) |
| TT/AA | 1.00 (reference) | 2.74 (1.30–5.79) | 1.00 (reference) | 3.16 (1.41–7.12) |
| MTHFR 677/TSER | ||||
| CC+CT/3R3R | 1.00 (reference) | 1.85 (1.30–2.65) | 1.00 (reference) | 2.84 (1.85–4.35) |
| CC+CT/2R3R+2R2R | 1.00 (reference) | 1.12 (0.67–1.89) | 1.00 (reference) | 2.57 (1.44–4.58) |
| TT/3R3R | 1.00 (reference) | 2.04 (0.78–5.33) | 1.00 (reference) | 5.99 (1.94–18.45) |
| TT/2R3R+2R2R | 1.00 (reference) | 4.63 (1.26–16.96) | 1.00 (reference) | 1.60 (0.41–6.24) |
| MTHFR 677/TS 1494 | ||||
| CC+CT/0bp0bp | 1.00 (reference) | 2.19 (1.44–3.33) | 1.00 (reference) | 2.51 (1.56–4.04) |
| CC+CT/0bp6bp+6bp6bp | 1.00 (reference) | 1.15 (0.76–1.75) | 1.00 (reference) | 3.07 (1.86–5.07) |
| TT/0bp0bp | 1.00 (reference) | 1.18 (0.39–3.50) | 1.00 (reference) | 2.60 (0.78–8.65) |
| TT/0bp6bp+6bp6bp | 1.00 (reference) | 5.22 (1.72–15.84) | 1.00 (reference) | 3.81 (1.19–12.22) |
| MTHFR 677/TSER/TS 1494 | ||||
| CC+CT/3R3R/0bp0bp | 1.00 (reference) | 2.56 (1.61–4.09) | 1.00 (reference) | 3.03 (1.74–5.25) |
| CC+CT/3R3R/0bp6bp+6bp6bp | 1.00 (reference) | 1.16 (0.65–2.07) | 1.00 (reference) | 2.61 (1.30–5.26) |
| CC+CT/2R3R+2R2R/0bp0bp | 1.00 (reference) | 0.92 (0.32–2.61) | 1.00 (reference) | 1.29 (0.46–3.68) |
| CC+CT/2R3R+2R2R/0bp6bp+6bp6bp | 1.00 (reference) | 1.14 (0.61–2.10) | 1.00 (reference) | 3.55 (1.71–7.37) |
| TT/3R3R/0bp0bp | 1.00 (reference) | 0.97 (0.28–3.40) | 1.00 (reference) | 3.97 (0.95–16.58) |
| TT/3R3R/0bp6bp+6bp6bp | 1.00 (reference) | 5.21 (0.87–31.18) | 1.00 (reference) | 20.13 (1.76–230.92) |
| TT/2R3R+2R2R/0bp0bp | 1.00 (reference) | 0.41 (0.01–17.12) | 1.00 (reference) | 0.36 (0.01–9.49) |
| TT/2R3R+2R2R/0bp6bp+6bp6bp | 1.00 (reference) | 12.05 (1.78–81.53) | 1.00 (reference) | 1.71 (0.28–10.42) |
a
Models adjusted for age, gender, hypertension, diabetes mellitus and genotypes. The results of genetic factors and combinations containing lower OR values compared to total (hypertension or diabetes mellitus) were eliminated. MTHFR, methylenetetrahydrofolate reductase; TS, thymidylate synthase; TSER, TS enhancer region.