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Proposed mechanisms of cycloclavine formation. EasA is an Old Yellow Enzyme homologue, EasG is an NADPH-dependent reductase, and EasH is annotated as an α-ketoglutarate-dependent, non-heme iron oxygenase; R=OH or Cl. a) EasH hydroxylates or halogenates 9. b) EasH abstracts a hydride ion from 9. c) EasH abstracts a hydrogen atom from 9.
