Table III.

GRADE framework assessment of eligible studies.

	Design		Quality assessment
Outcome	Experiment	Control	Risk of bias	Inconsistency	Indirectness	Imprecision	No. of eligible studies	Quality
pCR	Platinum-based regimen	Non-platinum regimen	Serious	No serious inconsistency	No serious indirectness	No serious imprecision	5	Moderate
ORR	Platinum-based regimen	Platinum-based regimen	Serious	No serious inconsistency	No serious indirectness	No serious imprecision	4	Moderate

GRADE, Grading of Recommendations Assessment, Development and Evaluation; pCR, pCR, pathological complete response; ORR, overall response rate.