Table I.
Effects of CD and CA on the activities of enzymatic antioxidants in the brain.
| Groups | SOD (U/mg protein) | CAT (U/mg protein) | GPx (nmol/min/mg protein) | GST (nmol/min/mg protein) |
|---|---|---|---|---|
| Control | 7.22±0.19 | 4.35±0.1 | 2.87±0.13 | 5.59±0.45 |
| Cd (5 mg/kg) | 4.11±0.13a | 1.56±0.07a | 1.38±0.06a | 3.18±0.21a |
| CA (60 mg/kg) | 7.91±0.17a,b | 3.70±0.08a,b | 3.95±0.18a,b | 4.62±0.17b |
| Cd (5 mg/kg) + CA (60 mg/kg) | 7.10±0.09b | 4.20±0.14b | 4.10±0.15a,b | 5.43±0.10b |
Values are expressed as mean ± standard deviation for 6 rats in each group.
P<0.05 compared with the control group
P<0.05 compared with the Cd group. Units of measurement are: for SOD, U/mg protein where 1 unit is equal to the amount of enzyme that causes a 50% suppression of the reduction of nitro blue tetrazolium/min/mg of protein; for CAT, U/mg protein where 1 unit corresponds to 1 nmol H2 consumed/min/mg protein; for GPx, nmol GSH oxidized/min/mg protein; and for GST, nmol GSH-CDNB conjugate formed/min/mg protein. Cd, cadmium; CA, chlorogenic acid; SOD, superoxide dismutase; CAT, catalase; GPx, glutathione peroxidase; GST, glutathione S-transferase; GSH, reduced glutathione; CDNB, 1-chloro-2,4-dinitrochlorobenzene.