Figure 2.

Effects of minocycline and indomethacin alone or in combination on paclitaxel-induced thermal hyperalgesia in female and male BALB/c mice. Reaction latency times of (A) female mice and (B) male mice (taken at day 7 post first administration of paclitaxel [pacli]) at different times after treatment with minocycline (mino, 50 mg/kg), indomethacin (indo, 1 or 10 mg/kg) alone or in combination in the hot plate test (n = 8 for female mice and n = 10-11 for male mice). *p < 0.05 and **p < 0.01 compared to vehicle only group (without hyperalgesia) at the same time point after treatment and ##p < 0.01 compared to mice with paclitaxel-induced hyperalgesia treated with vehicle. Percentage change in reaction latency times from baseline values (taken at day 7 post first administration of paclitaxel) of (C) female mice and (D) male mice after treatment with minocycline, indomethacin alone or in combination in the hot plate test. *p < 0.05 and **p < 0.01 compared to paclitaxel + vehicle-treated group at the same time point after treatment and ##p < 0.01 between mice treated with minocycline or indomethacin alone and those treated with minocycline + indomethacin.