Table 3.
Significant genes with upregulated expression in CD14+ peripheral blood cells from patients with pancreatic ductal adenocarcinoma
| P-value | Fold-change (PK/healthy) | Symbol | Description | Accession† | Defined gene list |
|---|---|---|---|---|---|
| 5.10E-06 | 1.666666667 | DLC1 | Deleted in liver cancer 1 | NM_001164271 | |
| 2.21E-05 | 2.083333333 | HPGD | Hydroxyprostaglandin dehydrogenase 15-(NAD) | NM_000860 | |
| 2.99E-05 | 1.851851852 | EPS8 | Epidermal growth factor receptor pathway substrate 8 | NM_004447 | |
| 4.11E-05 | 1.612903226 | DENND1B | DENN/MADD domain containing 1B | NM_001142795 | |
| 4.23E-05 | 1.851851852 | AMIGO2 | Adhesion molecule with Ig-like domain 2 | NM_001143668 | |
| 0.0000435 | 2.631578947 | MSR1 | Macrophage scavenger receptor 1 | NM_002445 | Phagosome |
| 8.58E-05 | 1.724137931 | EPSTI1 | Epithelial stromal interaction 1 (breast) | NM_001002264 | |
| 0.0000927 | 2.083333333 | ARID5B | AT rich interactive domain 5B (MRF1-like) | NM_001244638 | |
| 0.0001720 | 1.587301587 | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | NM_001135651 | Bone remodelling, double-stranded RNA-induced gene expression, inactivation of GSK3 by AKT causes accumulation of β-catenin in alveolar macrophages, regulation of EIF2, Toll-like receptor pathway, hepatitis c, protein processing in endoplasmic reticulum |
| 0.0001827 | 1.666666667 | FBXO38 | F-box protein 38 | NM_001271723 | |
| 0.0002219 | 3.333333333 | UTY | Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | NM_001258249 | |
| 0.0002584 | 1.694915254 | FKBP5 | FK506 binding protein 5 | NM_001145775 | |
| 3.47E-04 | 1.639344262 | LRP12 | Low density lipoprotein receptor-related protein 12 | NM_001135703 | |
| 0.0003545 | 16.12903226 | DDX3Y | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | NM_001122665 | RIG-I-like receptor signaling pathway |
| 0.0004157 | 17.85714286 | RPS4Y2 | Ribosomal protein S4, Y-linked 2 | NM_001039567 | |
| 4.29E-04 | 2.777777778 | FAM20A | Family with sequence similarity 20, member A | NM_001243746 | |
| 0.0004546 | 2.040816327 | CLU | Clusterin | NM_001831 | |
| 4.59E-04 | 17.54385965 | RPS4Y1 | Ribosomal protein S4, Y-linked 1 | NM_001008 | Ribosome |
| 5.09E-04 | 1.5625 | VWCE | Von Willebrand factor C and EGF domains | NM_152718 | |
| 5.50E-04 | 1.639344262 | CDK6 | Cyclin-dependent kinase 6 | NM_001145306 | Cell cycle: G1/s checkpoint, cyclins and cell cycle regulation, estrogen-responsive protein EFP controls cell cycle and breast tumors growth, influence of Ras and Rho proteins on G1 to S transition, cell cycle, chronic myeloid leukemia, glioma, melanoma, non-small-cell lung cancer, p53 signaling pathway, pancreatic cancer, pathways in cancer, small-cell lung cancer |
| 5.57E-04 | 1.612903226 | P2RY1 | Purinergic receptor P2Y, G-protein coupled, 1 | NM_002563 | Neuroactive ligand–receptor interaction |
| 0.0005792 | 2.083333333 | PRDM1 | PR domain containing 1, with ZNF domain | NM_001198 | |
| 0.0005939 | 1.785714286 | IFI44 | Interferon-induced protein 44 | NM_006417 | |
| 6.98E-04 | 1.515151515 | MT2A | Metallothionein 2A | NM_005953 | |
| 0.0007509 | 1.694915254 | LY6E | Lymphocyte antigen 6 complex, locus E | NM_001127213 | |
| 0.0008281 | 1.612903226 | BAMBI | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) | NM_012342 | |
| 0.0008473 | 1.754385965 | C2 | Complement component 2 | NM_000063 | Classical complement pathway, complement pathway, lectin-induced complement pathway, complement and coagulation cascades, Staphylococcus aureus infection, systemic lupus erythematosus |
| 1.09E-03 | 2 | TTTY15 | Testis-specific transcript, Y-linked 15 (non-protein coding) | NR_001545 | |
| 1.27E-03 | 1.851851852 | NGFRAP1 | Nerve growth factor receptor (TNFRSF16) associated protein 1 | NM_014380 | Neurotrophin signaling pathway |
| 0.0013756 | 2.222222222 | PDK4 | Pyruvate dehydrogenase kinase, isozyme 4 | NM_002612 | |
| 1.52E-03 | 2.564102564 | ZFY | Zinc finger protein, Y-linked | NM_001145275 | |
| 1.64E-03 | 1.515151515 | CABLES1 | Cdk5 and Abl enzyme substrate 1 | NM_001100619 | |
| 1.68E-03 | 1.694915254 | TNIK | TRAF2 and NCK interacting kinase | NM_001161560 | |
| 0.0018725 | 1.538461538 | CHAF1B | Chromatin assembly factor 1, subunit B (p60) | NM_005441 | BTG family proteins and cell cycle regulation |
| 0.0018950 | 1.724137931 | BTG3 | BTG family, member 3 | NM_001130914 | RNA degradation |
| 0.0019480 | 1.612903226 | HDGFRP3 | Hepatoma-derived growth factor, related protein 3 | NM_016073 | |
| 2.08E-03 | 2.631578947 | PPARG | Peroxisome proliferator-activated receptor gamma | NM_005037 | Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression, nuclear receptors in lipid metabolism and toxicity, role of PPAR-γ coactivators in obesity and thermogenesis, visceral fat deposits and the metabolic syndrome, Huntington's disease, osteoclast differentiation, pathways in cancer, PPAR signaling pathway, thyroid cancer |
| 2.21E-03 | 1.587301587 | MAF | V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) | NM_001031804 | |
| 2.31E-03 | 1.639344262 | TFDP2 | Transcription factor Dp-2 (E2F dimerization partner 2) | NM_001178138 | Cell cycle |
| 0.0023519 | 1.5625 | FOXC1 | Forkhead box C1 | NM_001453 | |
| 2.36E-03 | 1.587301587 | PLAC8 | Placenta-specific 8 | NM_001130715 | |
| 2.41E-03 | 1.666666667 | BEX1 | Brain expressed, X-linked 1 | NM_018476 | |
| 0.0024547 | 1.515151515 | PIM1 | Pim-1 oncogene | NM_001243186 | Acute myeloid leukemia, Jak-Stat signaling pathway |
| 0.0024567 | 2.173913043 | CST7 | Cystatin F (leukocystatin) | NM_003650 | |
| 0.0025775 | 1.960784314 | PCSK6 | Proprotein convertase subtilisin/kexin type 6 | NM_002570 | |
| 0.0029609 | 1.639344262 | REST | RE1-silencing transcription factor | NM_001193508 | Huntington's disease |
| 0.0029864 | 1.666666667 | FKBP11 | FK506 binding protein 11, 19 kda | NM_001143781 | |
| 0.0029868 | 1.639344262 | OASL | 2′-5′-oligoadenylate synthetase-like | NM_001261825 | |
| 0.0033994 | 1.754385965 | CD226 | CD226 molecule | NM_006566 | Cell adhesion molecules |
| 3.85E-03 | 1.538461538 | PNMA1 | Paraneoplastic Ma antigen 1 | NM_006029 |
PK, pancreatic cancer patients.