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Cytotoxicity of doxorubicin (DOX) and aspartate-modified DOX (Asp-DOX) in different cancer cell lines in vitro. Cytotoxicity levels of DOX and Asp-DOX to the LAT1-positive cell lines HCT116 (a), HepG2 (b), and MCF7 (c), and the LAT1-negative cell line H1299 (d) were determined by their inhibition of cancer cells through the MTT method.
