Table 3.

Uptake of doxorubicin (DOX) and aspartate-modified DOX (Asp-DOX) in HepG2 (LAT1-positive) and H1299 (LAT1-negative) cell lines at different doses (10, 20, and 50 μg/mL) in vitro (n = 3)

	Uptake of DOX, μg/mL		Uptake of Asp-DOX, μg/mL
	HepG2	H1299	HepG2	H1299
10 μg/mL	0.21 ± 0.030	0.20 ± 0.059	0.48 ± 0.019**	ND**
20 μg/mL	0.44 ± 0.032	0.33 ± 0.019	1.45 ± 0.046**	0.016 ± 0.0012**
50 μg/mL	0.70 ± 0.079	0.69 ± 0.055	2.63 ± 0.171**	0.018 ± 0.0022**

^*P < 0.05

^**P < 0.01.