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. 2015 May 26;106(6):747–756. doi: 10.1111/cas.12672

Table 4.

Bidirectional transport of doxorubicin (DOX) and aspartate-modified DOX (Asp-DOX) in MDR1-overexpressing MDCK cells, assessed by the Transwell method (n = 3)

Papp (10−6 cm/s) PDR
A–B B–A
DOX (50 μg/mL) 0.53 ± 0.093 6.63 ± 0.328 13.01 ± 1.425
Asp-DOX (50 μg/mL) 0.67 ± 0.045 0.87 ± 0.073 1.30 ± 0.110*
*

P < 0.01. A–B, Direction of transport from apical to basolateral profile; B–A, direction of transport from basolateral to apical profile; Papp, apparent permeability; PDR, the efflux rate.