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Efficacy of combination therapy according to RECIST
| Response | Level 1 (n = 2) | Level 2a (n = 3) | Level 2b (n = 3) | Level 3 (n = 4) | Total (n = 12) |
|---|---|---|---|---|---|
| CR | 1 | 0 | 0 | 0 | 1 |
| PR | 0 | 2 | 0 | 3 | 5 |
| SD | 0 | 1 | 2 | 1 | 4 |
| PD | 1 | 0 | 0 | 0 | 1 |
| NE | 0 | 0 | 1 | 0 | 1 |
| Response rate (CR+PR) | 50.0% | 66.7% | 0.0% | 75.0% | 50.0% (95% CI, 21.1–78.9) |
| Disease control rate (CR+PR+SD for ≥16 weeks) | 50.0% | 100.0% | 66.7% | 100.0% | 83.3% (95% CI, 51.6–97.9) |
CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; NE, not evaluable
