Figure 4.

Tissue Classification of Genes Expressed Differently between WT and Aberrant Teratomas

Number of genes differentially expressed in chromosomally aberrant teratomas compared with teratomas initiated from diploid cells. Gene were considered differentially expressed when changed over 2-fold compared with control (^∗p < 0.001). Teratomas from cells carrying trisomy of chromosome 12 (T12, n = 5) showed a significant number of upregulated genes enriched for brain, fetal brain, spinal cord, and joint as well as downregulated genes enriched for liver and fetal liver, colon, small intestine, lung, and skeletal muscle compared with WT teratomas (n = 5). In contrast, teratomas from cells carrying trisomy of chromosome 21 (T21, n = 4) showed significant number of downregulated genes specific for skeletal muscle only, with a significant number of upregulated genes enriched for brain, fetal brain, spinal cord, and joint.