Initial Gene Regulation by OSKM
(A) Comparison of gene expression in OSKM-induced cells between days 0 and 3. Differentially expressed genes (>4-fold) related to “histone modification (GO: 0016570)” or “transcription factor binding (GO: 0008134)” are shown by red dots.
(B) GO analysis of upregulated and downregulated genes at day3. Dashed line represents 0.05 FDR.
(C and D) Comparison of (C) histone modification and (D) OSKM binding level in fibroblast stage with gene expression changes at day3. The x axis represents the rank of genes sorted by increasing order of log2(day 3/day 0) values. The y axis represents log2(ChIP/input). Colors represent log10(count).
See also Figure S1.