Table 2.
Selected protein function ontology classes including proteins involved in inflammation and immune response processes
| Accession | Protein functions and names | RSC |
|---|---|---|
| Defense response | ||
| P05164 | Myeloperoxidase | 5.62 |
| B6E141 | Haptoglobin (Zonulin) | 4.78 |
| O77774 | Neutrophil cytosol factor 1 | 4.70 |
| P0C0S4 | Histone H2A.Z | 4.65 |
| P54230 | Cathelicidin-1 | 4.09 |
| P70248 | Unconventional myosin-If | 3.79 |
| Q00655 | Tyrosine-protein kinase SYK | 3.64 |
| P50415 | Cathelicidin-3 | 3.57 |
| P06800 | Receptor-type tyrosine-protein phosphatase C | 3.07 |
| P80190 | Lysozyme C, kidney isozyme | 3.07 |
| P56425 | Cathelicidin-7 | 2.85 |
| Q2HJ57 | Coactosin-like protein | 2.48 |
| P79362 | Cathelicidin-2 | 2.46 |
| Q60710 | SAM domain and HD domain-containing protein 1 | 2.35 |
| P17453 | Bactericidal permeability-increasing protein | 2.33 |
| Q92608 | Dedicator of cytokinesis protein 2 | 2.30 |
| P80025 | Lactoperoxidase | 1.50 |
| Immune response | ||
| P70248 | Unconventional myosin-If | 3.79 |
| P15497 | Apolipoprotein A-I | 2.10 |
| Q29477 | Lactotransferrin | 4.33 |
| Q00655 | Tyrosine-protein kinase SYK | 3.64 |
| O46521 | Cytochrome b-245 light chain | 3.12 |
| Q3UP87 | Neutrophil elastase | 2.77 |
| Q3MHR7 | Actin-related protein 2/3 complex subunit 2 | 3.39 |
| Q92608 | Dedicator of cytokinesis protein 2 | 2.30 |
| P06800 | Receptor-type tyrosine-protein phosphatase C | 3.07 |
| Q60710 | SAM domain and HD domain-containing protein 1 | 2.35 |
| P13796 | Plastin-2 | 2.30 |
| P47845 | Galectin-3 | 1.85 |
| P11215 | Integrin alpha-M | 1.55 |
| Innate immune response | ||
| Q29477 | Lactotransferrin | 4.33 |
| P70248 | Unconventional myosin-If | 3.79 |
| Q00655 | Tyrosine-protein kinase SYK | 3.64 |
| Q3MHR7 | Actin-related protein 2/3 complex subunit 2 | 3.39 |
| O46521 | Cytochrome b-245 light chain | 3.12 |
| P28783 | Protein S100-A9 | 2.79 |
| P28782 | Protein S100-A8 | 2.65 |
| Q60710 | SAM domain and HD domain-containing protein 1 | 2.35 |
| P47845 | Galectin-3 | 1.85 |
| P11215 | Integrin alpha-M | 1.55 |
| Inflammatory response | ||
| Q8SPQ0 | Chitinase-3-like protein 1 | 5.09 |
| O77774 | Neutrophil cytosol factor 1 | 4.70 |
| O46521 | Cytochrome b-245 light chain | 3.12 |
| Q2UVX4 | Complement C3 | 2.85 |
| P28783 | Protein S100-A9 | 2.79 |
| Q3UP87 | Neutrophil elastase | 2.77 |
| P28782 | Protein S100-A8 | 2.65 |
| P15497 | Apolipoprotein A-I | 2.10 |
| P98066 | Tumor necrosis factor-inducible gene 6 protein | 2.08 |
| Peptidase activity | ||
| Q29477 | Lactotransferrin | 4.33 |
| Q2UVX4 | Complement C3 | 2.85 |
| P28783 | Protein S100-A9 | 2.79 |
| Q3UP87 | Neutrophil elastase | 2.77 |
| P28782 | Protein S100-A8 | 2.65 |
| P80209 | Cathepsin D | 2.27 |
| P81286 | Plasminogen | 2.25 |
| P23004 | Cytochrome b-c1 complex subunit 2, mitochondrial | 2.18 |
| Q27970 | Calpain-1 catalytic subunit | 1.85 |
| Integrin-mediated signaling pathway | ||
| Q5VI41 | Integrin beta-2 | 6.53 |
| Q00655 | Tyrosine-protein kinase SYK | 3.64 |
| P11215 | Integrin alpha-M | 1.55 |
| Neutrophil chemotaxis | ||
| Q00655 | Tyrosine-protein kinase SYK | 3.64 |
| P28783 | Protein S100-A9 | 2.79 |
| P28782 | Protein S100-A8 | 2.65 |
| P11215 | Integrin alpha-M | 1.55 |
| Acute-phase response | ||
| B6E141 | Haptoglobin (Zonulin) | 4.78 |
| P85521 | Scavenger receptor cysteine-rich type 1 protein | 2.49 |
| Protein citrullination | ||
| O02849 | Protein-arginine deiminase type-3 | 2.86 |
| Q9UM07 | Protein-arginine deiminase type-4 | 2.38 |
| Secretory granule | ||
| P05164 | Myeloperoxidase | 5.62 |
| Q3UP87 | Neutrophil elastase | 2.77 |
All differences were statistically significant (P < 0.05; Beta-binomial test).