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DRM1 and DRM2 are enriched in membrane raft markers: GM1 and Lck. As shown, both DRM1 and DRM2 were enriched in GM1 (dot blot) and in total cholesterol. Moreover, the raft-associated protein Lck was enriched in these fractions. In contrast, the transferrin receptor (CD71), a nonraft-associated protein, was found in the soluble fraction.
