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. 2015 Jun 12;8:1443–1449. doi: 10.2147/OTT.S84467

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© 2015 Xing et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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CpG-ODN 7909 downregulated Oct-4 expression in H460R cells when combined with IR.

Notes: Illustrative Western blots and densitometric analysis demonstrated that CpG-ODN 7909 downregulated Oct-4 expression in H460R cells in a dose-dependent manner. This reduction could be blocked by the co-treatment of CQ. *P<0.05 vs 0 µg/mL; (a) P<0.05 vs IR group; (b) P<0.05 vs control group; and (c) P<0.05 vs CpG group.

Abbreviations: CpG-ODN 7909, CpG oligodeoxyribonucleotide 7909; Oct-4, octamer-4; H460R, radioresistant H460; IR, irradiation; CQ, chloroquine; IR group, irradiated group.