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. 2015 Jun 12;8:1443–1449. doi: 10.2147/OTT.S84467

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© 2015 Xing et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effect of CpG-ODN 7909 on G2/M phase arrest in H460R cells.

Notes: (A) Flow cytometric analysis of cell cycle distribution. (B) The proportion of cells in the G2/M phase. CpG-ODN 7909 or IR could increase the proportion of cells in the G2/M phase. However, combined treatment showed a much higher percentage in the G2/M phase compared to either treatment alone. This reinforcing effect could be blocked by the co-treatment of CQ, suggesting that CpG-ODN 7909 could prolong cell-cycle arrest in the G2/M phase and enhance radiosensitivity through TLR9 signaling. (a) P<0.05 vs IR group; (b) P<0.05 vs control group; and (c) P<0.05 vs CpG group.

Abbreviations: CpG-ODN 7909, CpG oligodeoxyribonucleotide 7909; H460R, radioresistant H460; IR, irradiation; CQ, chloroquine; TLR9, toll-like receptor 9.