Table 2.
Comparison of radiosensitivity of H460R cells treated with IR, CpG-ODN 7909, or CQ
| Group | D0 | Dq | N | SER |
|---|---|---|---|---|
| IR | 1.569 | 2.481 | 4.862 | – |
| IR + CpG | 1.282 | 1.765 | 3.961 | 1.224 |
| IR + CpG + CQ | 1.515 | 2.132 | 4.086 | 1.036 |
| IR + CQ | 1.519 | 2.614 | 5.590 | 1.033 |
Notes: The D0, Dq, and N values of H460R cells treated with CpG-ODN 7909 plus IR were much lower relative to H460R cells irradiated alone, indicating the radiosensitization effect of CpG-ODN 7909 plus IR on H460R cells. The SER of D0 was 1.224. However, the radiation-enhancing effects disappeared after TLR9 activation was inhibited by CQ.
Abbreviations: H460R, radioresistant H460; IR, irradiation; CpG-ODN 7909, CpG oligodeoxyribonucleotide 7909; CQ, chloroquine; SER, sensitive enhancement ratio; TLR9, toll-like receptor 9.