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. 2015 Jun 12;9:3003–3016. doi: 10.2147/DDDT.S81656

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© 2015 Cui et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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OPN deficiency impaired DCs maturation and function after HBV antigenic stimulation in vitro.

Notes: DCs derived from BM of the WT and OPN^−/− mice were stimulated by HBV antigens. The histograms (A) and percentages (B–D) of CD80, CD86, and MHC-II molecules on the DC surface were detected by flow cytometry. Overlay plots are representative and show isotype control (shadow) and the expressions of the indicated molecules on DCs from WT mice (green line) or OPN^−/− mice (red line) in each group. (E) Levels of IL-12 in the BMDC culture supernatants following different stimulations were measured by ELISA. *P<0.05; **P<0.01.

Abbreviations: OPN, osteopontin; DCs, dendritic cells; HBV, hepatitis B virus; BM, bone marrow; WT, wild-type; HBcAg, hepatitis B core antigen; HBsAg, surface antigen of the hepatitis B virus; MHC, major histocompatibility complex; IL, interleukin; BMDC, bone marrow-derived dendritic cell; ELISA, enzyme-linked immunosorbent assay.