Table 1.

Mechanisms of cell death by anti-CD20 monoclonal antibodies

	Rituximab	Ofatumumab	Obinutuzumab
Antibody type	Type I	Type I	Type II
Format	Chimeric	Humanized	Humanized
CD20 binding site	Large loop	Large and small loops, closer to cell membrane	Large loop
Localization to lipid rafts	Yes	Yes	No
Complement-dependent cytotoxicity	High	High	Low
Antibody-dependent cellular cytotoxicity	Low	Low	High
Direct cell death	Low	Low	High