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Schematic diagram illustrates the regulation of Cx43 hemichannels by [Ca2+]i under OS. OS induces [Ca2+] rise as a result of extracellular Ca2+ influx and a release of Ca2+ from endoplasmic reticulum (ER). Elevated [Ca2+] promotes the increased presence of Cx43 hemichannels (Cx43 HC) on the cell surface.
