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. 2014 Aug 5;2:14015. doi: 10.1038/boneres.2014.15

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Copyright © 2014 Sichuan University

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Egfr^Wa5/+ mice exhibit accelerated osteoarthritis progression after DMM surgery. (a) Representative Safranin O/Fast Green staining images of mouse knee joints show increased articular cartilage degradation in Egfr^Wa5/+ mice 3 months after DMM surgery. Bottom panels are magnified images of top panels. (b) Total articular cartilage, uncalcified articular cartilage, and their respective thickness were quantified at both femoral condyle and tibial plateau regions. (c) Mankin score graded by blinded observers confirmed more articular cartilage destruction in Egfr^Wa5/+ mice (n=9) compared to WT (n=10) mice after DMM surgery. * P<0.05; ** P<0.01; *** P<0.001.