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. 2014 Nov 11;2:14033. doi: 10.1038/boneres.2014.33

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Copyright © 2014 Sichuan University

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Osteoblast numbers are significantly reduced in the early life of Nrf2^−/− mice. Quantitative histomorphometry of trabecular bone at the distal femur of control and Nrf2^−/− mice at 3, 6, 8, 12 and 24 weeks of age (n=4–6 mice/group/age). (a) Osteoblast number/bone length—number per 100 μm; (b) osteoclast number/bone length—number per 100 μm; (c) osteoid volume/bone volume; (d) osteoid surface/bone surface; (e) osteoid thickness. Values shown are mean±s.e.m.