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. 2015 Jun 9;3:15013. doi: 10.1038/boneres.2015.13

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Copyright © 2015 Sichuan University

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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^99mTc-MDP uptake rate peaks at 7 days post injury. (a) Representative SPECT/CT images of injured tibias at each time point. Yellow pseudo color represents the intensity of ^99mTc-MDP uptake. Note the growth-plate region in femurs and tibiae showed high ^99mTc-MD intensity. The arrows indicate the injury sites; (b) Quantitated ^99mTc-MDP uptake at the injury sites, which was normalized to the equivalent position of the intact tibia from the same animal. Each value is significantly changed (P <0.05) compared with previous one except the last time point. n, mouse number used for SPECT/CT scans; (c) ^99mTc-MDP uptake at the injury sites from each mouse throughout the healing process. Each line represents an individual animal.