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. 2015 Jun 18;13:195. doi: 10.1186/s12967-015-0533-x

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© Liu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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miR-409-3p targets the 3′-UTR of the oncogene NLK. a The putative binding sites of miR-409-3p in NLK 3′-UTR region were predicted. The matched seed sequences were indicated by vertical lines. b The minimum free energy (mfe) required for RNA hybridization was predicted by RNAhybrid software (mfe: −9.3 kcal/mol). c Schematic graph of the putative binding sites of miR-409-3p in the NLK 3′UTR and the mutation in miR-409-3p-binding sites. d miR-409-3p mimics down-regulated luciferase activities controlled by wild-type NLK 3′UTR (*P < 0.01), but did not affect luciferase activity controlled by mutant NLK 3′UTR. The results are means of three independent experiments ± SD.