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. 2015 Jan 29;4(6):808–818. doi: 10.1002/cam4.423

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© 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Expression of FilGAP and its associated molecules in normal lymph nodes. (A) Staining by hematoxylin and eosin (HE) and IHC for FilGAP, FLNa, integrin β2, ECT2, and Rac1 in the follicular region of lymph nodes. Boxes enclose a magnified view of the (a) germinal center, (b) mantle, and (c) paracortical regions. Note the perinuclear Rac1 immunoreactivity in the paracortical region (indicated by arrows). Original magnification, 200× and 400× (inset). (B) IHC scores for FilGAP, FLNa, integrin β2, ECT2, and cytoplasmic (cyto) Rac1 in the germinal center, mantle, and paracortical regions. The data shown are mean ± SD. FilGAP, a Rho GTPase-activating protein (GAP); IHC, immunohistochemistry; FLNa, filamin A; ECT2, epithelial cell transforming factor 2.