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Changes in possible body temperature during 50 min irradiation according to the correlation between total accumulated thermal output (TATO) (A: 549, B: 429–548, C: 428) and objective response. In patients with 429–548 TATO, patients with pathological complete response (ypCR) showed significant increase in temperature (B), but there was no increase in those with 428 or lower TATO (C). Data in the figure are presented as means with standard error (SEM).
