. 2015 Mar 14;4(6):897–902. doi: 10.1002/cam4.420

Table 1.

Average occurrence of lung lesions and their respective histopathology in K-ras^LA1/+ and Msh2^−/−; K-ras^LA1/+ mice at different time points

Genotype	Age	Hyperplasia	AAH	Adenoma	AdenoCA
K-ras^LA1/+	60–90 days	0.8 (0.49)	0.6 (0.4)	2.6 (0.98)	0.2 (0.2)
K-ras^LA1/+	90–120 days	0.56 (0.27)	1.38 (0.36)	2.81 (0.62)	0.25 (0.19)
Msh2^−/−; K-ras^LA1/+	60–90 days	0.23 (0.12)	0.92 (0.33)	2.61 (0.57)	0.38 (0.18)
Msh2^−/−; K-ras^LA1/+	90–120 days	0.44 (0.34)	1.11 (0.35)	6.33 (1.27)^*	0.89 (031)

Data represented as average number of tumor subtype per mouse lung with standard error of the mean (SEM) in parentheses. AAH, atypical adenomatous hyperplasia; AdenoCA, adenocarcinoma. Minimum N = 10 per group.

P ≤ 0.001; two-way ANOVA with Bonferroni posttest.