Table 2. Alterations in expression levels of alpha-synuclein and known interactors of alpha-synuclein in Braak 1–2 and PD compared to controls.
| Braak alpha-synuclein 1–2 compared to control | Braak alpha-synuclein 5–6 compared to control | |||
|---|---|---|---|---|
| Gene name | p-value | Fold change | p-value | Fold change |
| Synaptotagmin II | 7.5*10−5 | 1.92 | 0.14 | 1.19 |
| Synaptophysin | 4.3*10−4 | 2.35 | 4.3*10−4 | 2.05 |
| Synapsin 3 | 1.8*10−5 | 1.45 | 0.89 | 1.02 |
| Synphilin 1 | 0.03 | -1.19 | 0.01 | -1.2 |
| Complexin 2 | 0.04 | -1.12 | 8.7*10−4 | -1.18 |
| Synapsin 2 | 0.04 | 1.76 | 0.41 | -1.2 |
| Pra 1 | 0.13 | 1.26 | 0.19 | -1.18 |
| Syntaxin 1 | 0.15 | -1.21 | 3.0*10−5 | -1.76 |
| GLUr1 | 0.22 | -1.45 | 3.3*10−3 | -2.23 |
| Sptbn1 | 0.27 | -1.30 | 0.03 | 1.59 |
| Vamp2 | 0.39 | -1.22 | 2.9*10−3 | -1.91 |
| Complexin 1 | 0.52 | 1.19 | 0.19 | -1.36 |
| Tubulin | 0.56 | -1.17 | 3.4*10−3 | -2.05 |
| VMAT2 | 0.67 | -1.40 | 0.03 | -4.6 |
| Snap25 | 0.79 | 1.07 | 0.03 | -1.66 |
| Synapsin 1 | 0.82 | -1.08 | 2.9*10−3 | -2.43 |
| Dynamin 1 | 0.92 | -1.04 | 0.01 | -2.44 |
| alpha-synuclein | 0.68 | -1.12 | 9.6*10−4 | -2.34 |