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. 2015 Apr 25;34(1):38. doi: 10.1186/s13046-015-0157-2

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© van Haaften et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Synergistic drug combinations induce apoptosis. A: EPD and paclitaxel in single treatments induced apoptosis. Combination treatment showed an even higher caspase 3 activity. B: Cisplatin treatment alone did not induce apoptosis. Combination treatment of EPD and cisplatin showed a strong induction of caspase 3 activity. Inhibitor: Ac-DEVD-CHO; RFU: Relative Fluorescence Units.