Fig. 5.

a NF-κB level in brains harvested 3, 6, 12, 24, and 48 h after CLP. b Effects of PDTC on NF-κB level in brains harvested 12 h after CLP. Protein data values were normalized to actin level and reported in relative arbitrary units. NF-κB significantly increased at 12 and 24 h after CLP compared with that in sham-operated rats. The expression of NF-κB protein decreased in the hippocampus after PDTC injection. Data were expressed as mean ± SEM, n = 6/group. *P < 0.05 vs sham-operated group. ^# P < 0.05 vs 12 h or Veh + CLP group. NF-κB nuclear factor κB, CLP cecal ligation and puncture, PDTC pyrrolidine dithiocarbamate