Table 11.

Study Designs: Audiometric and Self-reported Outcomes.

Author, Year	Randomized	Prospective	Blinding of Participants	Blinding of Assessors/Outcome Measurement	Hearing Is the Primary Outcome
Pure-tone threshold audiometry and speech discrimination scores associated with aspirin in subjects without inflammatory conditions
Abdala, 200523	—	x	—	—	x
Day, 198925	—	x	x	x	x
Bonding, 197924	—	x	—	—	x
Johnsen, 198226	—	x	—	—	x
Pure-tone threshold audiometry and speech discrimination scores associated with aspirin in subjects with rheumatoid arthritis and connective tissue diseases
Jardini, 197837	x	x	x	x	x
Halla, 198835	—	x	—	—	x
Davis, 197934	—	x	x	x	—
Myers, 196538	—	x	—	—	x
Heyworth, 197236	—	x	—	—	x
Bernstein, 196733	—	x	—	—	x
Young, 198239	—	x	—	—	x
Self-reported evaluation of hearing results associated with aspirin in populations without inflammatory conditions
Curhan, 201250	—	x	—	—	x
Curhan, 201051	—	x	—	—	x
Miller, 197852	—	x	—	—	x
Miller, 197753	—	x	—	—	x
Porter, 197754	—	x	—	—	—
Self-reported evaluation of hearing results associated with aspirin in patients with rheumatoid arthritis
Huskisson, 197474	—	x	x	x	—
Halla, 198835	—	x	—	—	x
Impact of aspirin on hearing changes after noise exposures
Lindgren, 198656	—	x	—	—	x
McFadden, 198475	—	x	—	—	x
McFadden, 198357	—	x	—	—	x
Protective effects of aspirin when co-administered with aminoglycoside therapy
Sha, 200659; Chen, 200760	x	x	x	x	x
Behnoud, 200958	x	x	x	x	x