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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Nucl Med Biol. 2014 Dec 23;42(4):375–380. doi: 10.1016/j.nucmedbio.2014.12.012

Figure 4. Role of tumor antigen presence on radio-immunoconjugate distribution; and FcRn blocking.

Figure 4

A. Bio-distribution of 111In-DTPA-5A10 in tumor naïve BALB/c-nu mice showing a significantly lower accumulation in all organs compared to tumor bearing BALB/c-nu mice (Fig. 2B). B. The effect of nonspecific IgG1 mediated FcRn blocking on biodistribution of 111In-DTPA-5A10 in LNCaP xenografted NMRI-nu mice. Tumor uptake was not affected, but accelerated blood clearance and an increased accumulation in the spleen and salivary glands were observed. Tissues were harvested at 72 h post tracer injection.