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. 2015 Jun 19;15:474. doi: 10.1186/s12885-015-1445-0

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© SP et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Synergistic inhibition of cell proliferation by the combination of Tam and MSM and induction of apoptosis. (a) 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetra-zolium bromide assay for cell proliferation arrest by Tam, MSM, and their combinations in MCF-7 breast cancer cells. (b) Combination index plot for drug combination and table for various concentrations of Tam and MSM by Compusyn. (c) Apoptosis induced using MSM, Tam, or the combination in MCF-7 cells quantified using flow cytometry. Camptothecin was used as positive control. (d) Western blotting analysis of Bax protein levels in MCF-7 and T47D cells, and after treatment with Tam, MSM, or their combination for 24 h. (e) Graphical representation of Bax protein levels in MCF-7 and T47D cells, and after treatment with Tam, MSM, or their combination for 24 h