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. 2015 Jun 10;8:65. doi: 10.1186/s13045-015-0163-z

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© Loghavi et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Representative case of plasmablastic lymphoma. a Neoplastic cells have plasmablastic morphology, with a prominent nucleolus and moderate amount of cytoplasm. Mitotic figures and tingible-body macrophages are abundant and impart a “starry-sky” pattern (H&E, ×200). b The neoplastic cells are diffusely positive for EBV-encoded RNA (EBER) by colorimetric in situ hybridization (×200). c CD20 expression is absent. This case was negative for CD19 and positive for CD38 by flow cytometry (data not shown) (×200). d MYC overexpression is positive by immunohistochemistry (×200). e Karyotype of case 30 (nasopharyngeal mass): 46, XY, del(6)(q23q29),t(8;14)(q24;q32), add(20)(p13). f Fluorescence in situ hybridization using a dual-color break-apart probe specific for the MYC locus on formalin-fixed paraffin-embedded tissue (case 30) showing split signals in ~80 % of nuclei (circle: fusion signal; arrow: split signal)