Table 4.
Survey questionnaire score decline rates comparing follow-up versus baseline values.
| UMSARS I | UMSARS II | UMSARS Total | MMSE* | SF-36 Physical Health Component | SF-36 Mental Health Component | COMPASS Select/COMPASS Select Change** | |
|---|---|---|---|---|---|---|---|
| Baseline | |||||||
| N | 175 | 175 | 175 | 173 | 175 | 175 | 175 |
| Score, mean (SD) | 25.01 (8.134) | 26.09 (9.271) | 51.10 (16.325) | 29.0 | 142.71 (67.292) | 201.53 (85.356) | 43.27 (18.864) |
| 95% CI | 23.80 – 26.22 | 24.71 – 27.47 | 48.67 – 53.54 | 27.0 – 30.0 | 132.67 – 152.75 | 188.79 – 214.26 | 40.45 – 46.08 |
| 6-month follow-up | |||||||
| N | 110 | 90 | 90 | 85 | 88 | 88 | 108 |
| Score, mean (SD) | 26.08 (8.123) | 28.01 (7.875) | 53.97 (14.242) | 29.0 | 132.85 (68.304) | 200.20 (84.370) | 41.01 (31.611) |
| 95% CI | 24.55 – 27.62 | 26.36 – 29.66 | 50.98 – 56-95 | 27.0 – 29.5 | 118.38 – 147.33 | 182.32 – 218.08 | 34.98 – 47.04 |
| Score difference, mean (SD) | 1.98 (4.286) | 3.00 (4.264) | 4.78 (7.181) | 0.0 | -19.79 (50.541) | -11.15 (75.273) | - |
| 95% CI | 1.17 – 2.79 | 2.11 – 3.89 | 3.27 – 6.28 | -1.0 – 1.0 | -30.50 – -9.08 | -27.10 – 4.80 | - |
| Mean percent change | 8.95 | 15.54 | 10.93 | - | -7.36 | 10.65 | - |
| 12-month follow-up | |||||||
| N | 96 | 79 | 79 | 74 | 77 | 77 | 92 |
| Score, mean (SD) | 26.67 (8.207) | 28.72 (7.326) | 55.11 (13.503) | 29.0 | 125.77 (65.956) | 201.73 (80.463) | 38.79 (30.066) |
| 95% CI | 25.00 – 28.33 | 27.08 – 30.36 | 52.09 – 58.14 | 27.0 – 30.0 | 110.80 – 140.74 | 183.47 – 220.00 | 32.56 – 45.02 |
| Score difference, mean (SD) | 3.91 (5.786) | 4.56 (4.974) | 7.58 (8.389) | 0.0 | -22.76 (56.665) | -7.50 (69.229) | - |
| 95% CI | 2.73 – 5.08 | 3.44 – 5.67 | 5.70 – 9.46 | -1.0 – 1.0 | -35.62 – -9.90 | -23.21 – 8.215 | - |
| Mean percent change | 21.04 | 23.88 | 18.93 | - | -11.01 | 7.46 | - |
| 18-month follow-up | |||||||
| N | 79 | 62 | 62 | 60 | 61 | 61 | 76 |
| Score, mean (SD) | 28.71 (8.051) | 29.24 (7.921) | 56.76 (13.732) | 29.0 | 127.27 (65.032) | 197.69 (75.910) | 39.07 (30.027) |
| 95% CI | 26.91 – 30.51 | 27.23 – 31.25 | 53.27 – 60.25 | 27.0 – 30.0 | 110.62 – 143.93 | 178.25 – 217.13 | 32.21 – 45.93 |
| Score difference, mean (SD) | 5.62 (5.862) | 5.57 (6.687) | 10.27 (10.470) | 0.0 | -33.32 (54.653) | -17.86 (86.367) | - |
| 95% CI | 4.31 – 6.93 | 3.87 – 7.26 | 7.62 – 12.93 | -1.8 – 0.8 | -47.32 – -19.32 | -39.98 – 4.26 | - |
| Mean percent change | 28.96 | 39.38 | 28.62 | - | -16.37 | 19.49 | - |
| 24-month follow-up | |||||||
| N | 69 | 53 | 53 | 49 | 52 | 52 | 67 |
| Score, mean (SD) | 29.43 (9.029) | 31.21 (8.402) | 59.72 (16.146) | 28.0 | 125.00 (69.210) | 185.32 (88.910) | 38.12 (28.412) |
| 95% CI | 27.27 – 31.60 | 28.89 – 33.52 | 55.27 – 64.17 | 26.5 – 29.5 | 105.73 – 144.27 | 160.57 -210.07 | 31.19 – 45.05 |
| Score difference, mean (SD) | 6.62 (7.129) | 7.25 (7.084) | 13.09 (13.447) | 0.0 | -30.74 (61.827) | -28.26 (86.061) | - |
| 95% CI | 4.91 – 8.34 | 5.29 – 9.20 | 9.39 – 16.80 | -2.0 – 1.0 | -47.95 – -13.53 | -52.22 – -4.30 | - |
| Mean percent change | 34.95 | 37.10 | 32.65 | - | -14.61 | 13.15 | - |
| 30-month follow-up | |||||||
| N | 50 | 40 | 40 | 38 | 37 | 37 | 45 |
| Score, mean (SD) | 30.46 (8.608) | 32.23 (9.071) | 61.35 (16.143) | 28.0 | 117.18 (67.312) | 193.78 (80.199) | 40.70 (29.367) |
| 95% CI | 28.01 – 32.91 | 29.32 – 35.12 | 56.19 – 66.51 | 25.8 – 29.0 | 94.73 – 139.62 | 167.04 – 220.51 | 31.88 – 49.52 |
| Score difference, mean (SD) | 7.04 (7.217) | 9.63 (9.437) | 16.80 (15.655) | -0.5 | -40.69 (57.383) | -13.48 (78.356) | - |
| 95% CI | 4.99 – 9.09 | 6.61 – 12.64 | 11.79 – 21.81 | -3.0 – 1.0 | -59.82 – -21.56 | -39.60 – 12.65 | - |
| Mean percent change | 39.74 | 73.29 | 50.35 | - | -19.16 | 30.08 | - |
| 36-month follow-up | |||||||
| N | 52 | 31 | 31 | 26 | 29 | 29 | 48 |
| Score, mean (SD) | 30.25 (9.778) | 30.97 (8.807) | 58.97 (17.398) | 28.5 | 119.95 (50.302) | 201.20 (71.747) | 42.18 (28.602) |
| 95% CI | 27.53 – 32.97 | 27.74 – 34.20 | 52.59 – 65.35 | 25.5 – 30.0 | 100.82 – 139.08 | 173.90 – 228.49 | 33.87 – 50.48 |
| Score difference, mean (SD) | 8.33 (7.816) | 8.48 (7.206) | 14.29 (12.820) | -1.0 | -37.95 (50.742) | -9.13 (74.272) | - |
| 95% CI | 6.15 – 10.50 | 5.84 – 11.13 | 9.59 – 18.99 | -3.0 – 1.0 | -57.25 – -18.65 | -37.38 – 19.12 | - |
| Mean percent change | 46.16 | 49.99 | 40.29 | - | -19.87 | 5.38 | - |
| 42-month follow-up | |||||||
| N | 27 | 19 | 19 | 18 | 19 | 19 | 27 |
| Score, mean (SD) | 29.56 (8.271) | 30.63 (9.476) | 58.58 (16.416) | 28.5 | 108.90 (46.141) | 195.12 (85.437) | 49.67 (26.998) |
| 95% CI | 26.28 – 32.83 | 26.06 – 35.20 | 50.67 – 66.49 | 27.0 – 30.0 | 86.66 – 131.13 | 153.94 – 236.30 | 38.99 – 60.35 |
| Score difference, mean (SD) | 7.67 (7.432) | 9.32 (6.617) | 14.95 (10.44) | 0.0 | -49.97 (41.699) | -21.57 (58.729) | - |
| 95% CI | 4.73 – 10.61 | 6.13 – 12.51 | 9.91 – 19.98 | -1.3 – 0.0 | -70.07 – -29.88 | -49.88 – 6.74 | - |
| Mean percent change | 41.73 | 48.93 | 37.02 | - | -28.89 | -4.82 | - |
| 48-month follow-up | |||||||
| N | 22 | 16 | 16 | 15 | 16 | 16 | 22 |
| Score, mean (SD) | 28.00 (8.384) | 28.06 (9.497) | 55.56 (16.379) | 29.0 | 119.91 (50.285) | 188.48 (76.206) | 42.43 (26.861) |
| 95% CI | 24.28 – 31.72 | 23.00 – 33.12 | 46.84 – 64.29 | 27.0 – 30.0 | 93.11 – 146.70 | 147.87 – 229.09 | 30.52 – 54.34 |
| Score difference, mean (SD) | 6.86 (5.330) | 7.31 (8.155) | 12.81 (9.731) | 0.0 | -49.03 (62.141) | -24.06 (66.674) | - |
| 95% CI | 4.50 – 9.23 | 2.97 – 11.66 | 7.63 – 18.00 | -1.0 – 1.0 | -82.14 – -15.92 | -59.59 – 11.47 | - |
| Mean percent change | 40.96 | 46.05 | 33.51 | - | -19.99 | -8.42 | - |
| 54-month follow-up | |||||||
| N | 15 | 7 | 7 | 6 | 7 | 7 | 15 |
| Score, mean (SD) | 32.73 (11.373) | 27.57 (14.258) | 56.00 (26.249) | 28.5 | 113.00 (53.947) | 192.24 (97.524) | 42.57 (32.874) |
| 95% CI | 26.43 – 39.03 | 14.39 – 40.76 | 31.72 – 80.28 | 23.3 – 29.3 | 63.12 – 162.89 | 102.04 – 282.43 | 24.36 – 60.77 |
| Score difference, mean (SD) | 7.73 (7.146) | 6.14 (8.934) | 13.29 (13.022) | -0.5 | -38.57 (35.447) | -30.41 (76.792) | - |
| 95% CI | 3.78 – 11.69 | -2.12 – 14.41 | 1.24 – 25.33 | -5.5 – 1.0 | -71.35 – -5.79 | -101.43 - 40.62 | - |
| Mean percent change | 32.62 | 23.18 | 27.03 | - | -20.97 | -3.24 | - |
| 60-month follow-up | |||||||
| N | 8 | 3 | 3 | 3 | 3 | 3 | 8 |
| Score, mean (SD) | 35.38 (14.212) | 40.67 (18.148) | 75.33 (34.196) | 29.0 | 103.67 (50.696) | 138.28 (67.368) | 56.19 (24.394) |
| 95% CI | 23.49 – 47.26 | -4.41 – 85.75 | -9.61 – 160.28 | - | -22.27 – 229.60 | -29.07 – 305.63 | 35.79 – 76.58 |
| Score difference, mean (SD) | 10.50 (8.799) | 16.67 (9.713) | 25.00 (18.028) | 1.0 | -54.17 (57.520) | -97.33 (61.791) | - |
| 95% CI | 3.14 – 17.86 | -7.46 – 40.79 | -19.78 – 69.78 | - | -197.06 – 88.72 | -250.83 – 56.16 | - |
| Mean percent change | 38.49 | 64.86 | 45.72 | - | -27.76 | -41.68 | - |
*
Median and IQR replace Mean (SD) and 95% CI due to non-normal distribution of the data for MMSE.
**
Baseline value is reported using COMPASS Select instrument and subsequent time points show summary using COMPASS Select Change instrument.