Table 4.
Logistic regression analysis of cytokines (IL-1β, IL-6, TNF-α and IFN-γ) genotypes polymorphism and alleles frequency in early onset sepsis compared with suspected patients
| Cytokine genes | OR (95% CI) | p value |
|---|---|---|
| IL-1β | ||
| T/T | 0.40 (0.13-1.28) | 0.123 |
| T/C | 1.00 | |
| C/C | 6.22 (2.11-17.45) | < 0.001 |
| IL-1β allele | ||
| T | 13.43 (7.27-25.71) | < 0.001 |
| C | ||
| IL-6 | ||
| G/G | 6.83 (3.06-15.22) | < 0.001 |
| G/C | 1.00 | |
| C/C | 4.90 (1.49-16.15) | 0.009 |
| IL-6 allele | ||
| G | 1.87 (1.11-3.20) | 0.002 |
| C | ||
| TNF-α | ||
| G/G | 2.82 (1.34-5.97) | 0.007 |
| G/A | 1.00 | |
| A/A | 0.74 (0.22-2.46) | 0.626 |
| TNF-α allele | ||
| G | 2.39 (1.36-4.27) | 0.001 |
| A | ||
| IFN-γ | ||
| A/A | 3.27 (1.56-6.84) | 0.002 |
| A/T | 1.00 | |
| T/T | 0.49 (0.12-1.98) | 0.317 |
| IFN-γ allele | ||
| A | 2.74 (1.56-4.90) | < 0.001 |
| T | ||