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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2015 Mar 14;8(3):694–702. doi: 10.1161/CIRCEP.114.002451

Figure 2.

Figure 2

Virtual Ito reconstitutes H2O2-induced (A) and hypokalemia-induced (B) EADs blocked by 4-AP. Row 1: Action potentials were elicited during pacing at PCL 6 s under control conditions. Row 2: H2O2 (1 mmol/L) or hypokalemia (2.7 mmol/L) induced EADs (*) during slow pacing at 6 s. Row 3: Ito blockade with 4-AP (2 mmol/L) suppressed EADs. Row 4: Representative parameter combinations of the virtual Ito that caused EADs to reappear. Rows 5–6: Representative parameter combinations of the virtual Ito that shortened APD and suppressed EAD reappearance by increasing the pedestal or Ito conductance.