Table 1.

Literature review of ventricular I_to1 parameters measured from different species. I_to1 density was reported either as peak or as difference between peak and pedestal. Inactivation kinetics were reported as a mono- (τ₁) or bi-exponential (τ₁, τ₂) decay time course.

Species	Ito1 Subtype	Temp (°C)	Density (pA/pF)	Gto (nS/pF)	τinact (ms)	Pedestal (% of peak)	References
Human
Normal	Ito1,f	35	-	-	8	-	7
	Ito1,f	21–24	8–14	0.06–0.11	46–75	16–22	7–10
Heart failure	Ito1,f	21–24	↓ ↔	↓ ↔	-	-	8–12
	Ito1,s	21–24	5–10	0.04–0.08	59–73	0–17	8–12
Rabbit
Normal	Ito1,s	34–37	10–18	0.08–0.14	10–20	4–25	3,13–17
	Ito1,s	25	33–38	0.25–0.29	30–35	15	17
Heart failure	Ito1,s	34–37	6–27	0.05–0.21	τ1: 7–8, τ2: 70–118	5–21	13–17
	Ito1,s	25	8	0.06	38–50	24	17
H2O2	Ito1,s	37	13	0.10	τ1: 65–80, τ2: 350	35	3
Canine
Normal	Ito1	36–37	17–46	0.13–0.35	18–36	-	3,9,18–23
	Ito1	24	20–22	0.15–0.17	34–49	0–16	9
Heart failure	Ito1	36–37	5–13	0.04–0.10	22–43	0–69	18–20,23
Rat
Normal	Ito1,f	37	20–22	0.15–0.17	45–97	-	24
	Ito1,f	20–25	9–39	0.07–0.30	16–55	7–40	21,25–28
LVH	Ito1,f	20–25	2–40	0.02–0.31	35–81	11–36	25–27,29,30
Chronic MI	Ito1,f	37	11–12	0.08–0.09	45–97	-	24

Temp: recording temperature; LVH: left ventricular hypertrophy; MI: myocardial infarction