. Author manuscript; available in PMC: 2016 Jun 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2015 Mar 14;8(3):694–702. doi: 10.1161/CIRCEP.114.002451

Table 2.

Statistical analysis of predicted vs. observed (G_to, τ_inact) parameter combinations causing EADs to reappear. A total of 480 observed (G_to, τ_inact) combinations of a virtual I_to with no pedestal (787 trials in 79 ventricular myocytes from 25 rabbit hearts) that did (EAD⁺) or did not (EAD⁻) cause H₂O₂-induced or hypokalemia-induced EADs to reappear at PCL 1 s are compared to theoretical predictions from a computer model.

No. of G_to-τ_inact Combinations		Observed
No. of G_to-τ_inact Combinations		EAD⁺	EAD⁻	Total
Predicted	EAD⁺	186	49	235
Predicted	EAD⁻	22	223	245
	Total	208	272	480

Positive Predictive Value [95% CI]		0.77 [0.67, 0.87]
Negative Predictive Value [95% CI]		0.93 [0.86, 0.99]
Sensitivity [95% CI]		0.92 [0.82, 0.99]
Specificity [95% CI]		0.72 [0.55, 0.89]
Positive Likelihood Ratio		3.3 [1.21, 5.41]
Negative Likelihood Ratio		0.11 [0.01, 0.26]
Odds Ratio [95% CI]		41.5 [1.8, 84.9]
P		<0.0001