Table 1. Binding affinities (IC50, pM) of ShK analogues.
| Peptide (pM) | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| Channel | ShK[28, 31] | ShK-186[46] | ShK-192[46] | [ESSS]ShK | [EESS]ShK | [EWSS]ShK |
| Kv1.1 | 18(3) | 6,900(500) | 22,000(3,000) | 1,327(386) {4} | 830(116) {5} | 5,371(912) {4} |
| Kv1.2 | 900(300) | ND | ND | ND | ND | >100,000 {4} |
| Kv1.3 | 11(2) | 71(4) | 140(19) | 657(79) {4} | 311(41) {4} | 34(8) {3} |
| KCa3.1 | 30,000(7000) | ND | >100,000 (>700) | ND | ND | >100,000 {3} |
| Kv1.1/Kv1.3 | 16 | 97 | 157 | 2.0 | 2.7 | 158 |
Numbers in parenthesis are standard errors of the mean (s.e.m.). Numbers in braces are number of cells tested for each blocker and channel.