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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: J Neurochem. 2015 Apr 30;134(1):56–65. doi: 10.1111/jnc.13104

Figure 5. Relationship between CACNA1C and CREB1 or C-MYC expression in METH-treated and untreated cells after 48 hr drug treatment.

Figure 5

A. CREB1 expression is significantly higher (p=0.03 by unpaired t-test) in METH-treated cells (n=13) compared to untreated cells (n=13) (left panel). CREB1 expression levels are positively correlated to CACNA1C expression levels in METH-treated cells but inversely correlated in untreated cells (right panel: ANCOVA, p=0.04).

B. Expression levels of MYC gene in METH-treated cells (n=14) is not significantly different (p=0.2 by unpaired t-test) than those found in untreated cells (n=14) (left panel). The right panel shows the scatter plot when data was stratified according to drug treatment; CACNA1C expression is significantly correlated with the expression levels of C-MYC genes (overall r=0.7, p=0.0002). However, the slopes of METH and untreated cells were not different from each other (ANCOVA p=0.5).