Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Nat Chem Biol. 2015 Jun 1;11(7):481–487. doi: 10.1038/nchembio.1821

Figure 3. Efficacy and toxicity of AmB ureas in mice.

Figure 3

Quantification of the fungal burden in the kidneys of C. albicans infected neutropenic mice 2, 6, 12 and 24 hours after a single IP injection of AmB, AmBMU or AmBAU at dosages of a. 1 mg/kg b. 4 mg/kg or c. 16 mg/kg. P-values are relative to AmB at each indicated time point, *, p≤0.05, **, p≤0.001, ***, p≤0.0001, d. Dose response toxicity assessed via determination of lethality upon single IV injection of AmB, AmBMU and AmBAU to healthy mice at doses of ranging from 0.5 to 64 mg/kg (5 mice per dosage). Mice were monitored for survival up to one day.