Table 2. Antifungal and human cell toxicity against clinically relevant cell lines.
MIC against yeast pathogens (C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, C. neoformans, and A. fumigatus) and minimum toxic concentration (MTC) causing 90% toxicity against human hTERT1 renal proximal tubule epithelial cells (RPTEC) and human primary RPTECs
| AmB | AmBMU | AmBAU | AmBCU | ||
|---|---|---|---|---|---|
| Candida albicans K1 | 0.25 | 0.5 | 0.5 | 0.5 | MIC (μg/mL) |
| Candida glabrata 760 | 0.06 | 0.25 | 0.25 | 1 | |
| Candida tropicalis 5810 | 0.06 | 1 | 1 | 2 | |
| Candida parapsilosis 22019 | 0.06 | 0.25 | 0.25 | 1 | |
| Cryptococcus neoformans H99 | 0.06 | 1 | 1 | 1 | |
| Cryptococcus neoformans 89–610 | 0.125 | 1 | 1 | 1 | |
| Cryptococcus neoformans T1 | 0.125 | 1 | 1 | 1 | |
| Aspergillus fumigatus 41 | 1 | 2 | 4 | 4 | |
| Aspergillus fumigatus 293 | 1 | 2 | 2 | 4 | |
| Aspergillus fumigatus 11628 | 0.5 | 0.5 | 1 | 2 | |
| Aspergillus fumigatus 14532 | 0.5 | 1 | 2 | 2 | |
|
| |||||
| hTERT1 RPTEC | 6.4 ± 1.3 | >80 | 37.6 ± 4.8 | >80 | MTC (μM) |
| Primary RPTEC | 2.4 ± 0.3 | 44.4 ± 2.1 | 11.3 ± 0.4 | >80 | |