Table 2. Classification of ACA arisen during long term treatment with IM.

Numbers and patient characteristics	b2a2 (e13a2): n = 36	b3a2 (e14a2): n = 29
t(9;22)(q34 ;q11) + ACA unbalanced	22 (61%)	25 (86%)
t(9 ;22)(q34 ;q11) + ACA balanced	14 (39%)	4 (14%)
Ratio (ACA unbalanced/balanced) *	1.6	6.3, p = 0.0246
Blast crises within observation period *	8 (22%)	7 (24%), p = 0.8554
Time to unbalanced ACA, median and range [months] #	23 (2–87)	21 (1–101), p = 0.9150
Time to BC, median and range [months] #	25 (6–48)	9 (3–15), p = 0.0124

ACA, additional clonal cytogenetic alteration

* Chi2-test

^# Mann-Whitney-U-test